Sorafenib and Mek Inhibition are Synergistic in Medullary Thyroid Carcinoma in Vitro
نویسندگان
چکیده
1 Divisions of Endocrinology, Diabetes and Metabolism 1 , Medical Oncology 2 , Department of Chemistry 3 , Center for Biostatistics 4 , and Department of Molecular Virology, Immunology and Genetics 5 , The Ohio State University Medical Center, The Ohio State University and The Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, The Ohio State University, Columbus, OH, USA; 6 Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, Korea; 7 Department of Otolaryngology, Head and Neck Surgery, Chungnam National University, Daejoon, Korea.
منابع مشابه
Sorafenib and Mek inhibition is synergistic in medullary thyroid carcinoma in vitro.
Clinical trials using kinase inhibitors have demonstrated transient partial responses and disease control in patients with progressive medullary thyroid cancer (MTC). The goal of this study was to identify potential combinatorial strategies to improve on these results using sorafenib, a multikinase inhibitor with activity in MTC, as a base compound to explore signaling that might predict synerg...
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BACKGROUND We hypothesized that autophagy inhibition would enhance the anticancer efficacy of ret protooncogene-targeted therapy in medullary thyroid cancer. METHODS Medullary thyroid cancer-1.1 and TT cells were treated with sunitinib or sorafenib in the presence or absence of everolimus, trehalose, or small interfering RNA directed against autophagy protein 5. RESULTS Sunitinib and sorafe...
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Thyroid cancer is a malignancy of the thyroid parenchymal cells. There are four main types of thyroid cancer: papillary thyroid cancer (PTC), follicular thyroid cancer (FTC), anaplastic thyroid carcinoma (ATC), and Medullary thyroid carcinoma (MTC). Medullary thyroid cancer (MTC) is a rare neuroendocrine tumor of the thyroid gland derived from parafollicular C-cells that produce calcitonin (CT...
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Introduction: Medullary thyroid carcinoma (MTC) is a rare thyroid cancer secreting calcitonin (CT) which is the most sensitive and specific tumor marker for MTC. This type of thyroid cancer is able to metastasize to different body areas including regional lymph nodes, lungs, liver and bone. The aim of this study was to assess the sensitivity and specificity of [99mTc-DMSA (V)] whole body ...
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Purpose: To investigate the antitumor activities of a histone deacetylase (HDAC) inhibitor, MPT0E028, plus sorafenib in liver cancer cells in vitro and in vivo. Experimental Design: Different liver cancer cell lines were exposed to sorafenib in the presence or absence ofMPT0E028, and cell viabilitywas determinedbyMTTassay. Effects of combined treatment on cell cycle and intracellular signaling ...
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تاریخ انتشار 2011